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This was similar to the outcome in the 20year UKPDS RCT, where metformin reduced all-cause mortality by 36 over a mean of 13 years, making it the safest and most effective drug ever patented for chronic degenerative disease. And note the cynical folly of the many manufacturers of the grossly overpromoted and overprescribed bisphosphonates and statins 8211; which have numerous serious adverse effects and should be last-ditch therapy in metastatic bone cancer and in rare serious hyperlipidemia, not for osteoporosis, not for mild to moderate lipidemia and certainly not over-the-counter as profiteers crave. ENDURINGLY BENEFICIAL MODERN CHRONIC DRUGS: The above drugs contrast with vey few modern chronic designer drugs that are still the leaders in their fields, whether as original or generic 8211; although none of them has been shown to address all-cause mortality and pathogenesis. Pfizer8217;s Norvascamlodipine is a rare modern designer exception 8211; dating from the late 1980s, it8217;s patent has only just run out- proving it8217;s enduring worth for longterm hypertension therapy as the premier 4th-line drug to add when reserpine 0.

The H1N1 swine flu virus is compatible with a bird flu virus that is endemic in poultry in Asia and they can produce hybrid viruses packed with greater killing power, Chinese researchers warned on Monday. The scientists made 127 hybrid viruses by mixing genes of the H1N1 and the avian H9N2 virus in a laboratory, and eight of the hybrids turned out to be more virulent than either parents when tested in mice. Upwards of 100,000 claims arising from the BP oil disaster in the Gulf of Mexico may never be paid, the beleaguered administrator of the oil company's compensation fund has acknowledged. quot;Here is the problem that I continually have to address ‚ roughly 80 of the claims that we now have in the queue lack proof,quot; Feinberg told foreign reporters in Washington. quot;That is a huge number.

May 16 - Japanese police besiege the headquarters of Aum Shinrikyo in Kamikuishiki, Yamanashi Prefecture at the foot of Mount Fuji, june 22 ‚ Japanese police rescue 365 hostages from a hijacked All Nippon Airways Flight 857 at Hakodate airport. The hijacker, Fumio Kutsumi, was armed with a screw driver, july 23 - House of Councillors election held. July 30 ‚ During an armed robbery at a Hachioji, Tokyo supermarket, November 18 - November 19 - APEC summit held in Osaka, the first in Japan. 1995 in Malaysia ‚ 1995 in Malaysia is the 38th anniversary of Malaysias independence.]