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Biologically active variants encompassed by the invention also include peptides that have been covalently linked with, for example, polyethylene glycol (PEG) or albumin. These covalent hybrid molecules possess certain desirable pharmaceutical properties such as an extended serum half-life after administration to a patient. Methods for creating PEG adducts involve chemical modification of monomethoxypolyethylene glycol to create an activated compound that will react with the peptides.

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