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ADULTS: But experts and numerous overdose reports ( only a few of which are noted below) reveal the truth, that at least oral DAILY, well over 50 000iu to 1 MILLION iud of vitamin D for monthsLONGTERM to up to 100 000IUD for months to 365 million iu over 10 years has to be taken to cause illness ie symptomatic hypercalcemia. Conversely, Chakraborty ea a t Roy Research Center, Kolkata, India, report (Lab Med. 2015) A nontoxic case of vitamin d toxicity, a woman who developed very high serum Vitamin D levels (746 ngmL, RI: 20 to 50) as a result of medication error. In spite of such high serum concentrations the patient was without any clinical symptoms and had normal serum calcium. The evidence base regarding the safety profile of Vitamin D supplementation in humans has been build through case reports, not dose titration RCTs to astronomical levels- which would be unethical. So while routine maintenance dose eg 600 000iumonth, or 4000- to 10 000iud, or 100 000iuwk in adults has never been reported to cause overdose toxicity, on vigorous chronic vitamin D3 (not calcium or D2) dosing for disease, obviously ideally baseline (or at least after say 2-3 months of trial of conservative vitamin D replacement) calcium, vitamin D and kidney function levels should be measured since very rarely, unexpected silent hypercalcemia may already be present.

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