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In a preferred embodiment, the subject invention provides peptides that are able to enhance nitric oxide (NO) activity andor elevate cellular guanosine monophosphate (cGMP). The peptides of the subject invention can also be used as inhibitors of phosphodiesterases (PDE). Through these mechanisms, the subject invention can be used advantageously to regulate blood in various tissues by, for example, effecting vasorelaxation, thereby providing therapeutic benefit in a variety of contexts. In a specific embodiment the subject invention provides three peptides, designated herein as P3, P4, and P6, which have been found to enhance the activity of endothelial cell nitric oxide synthase (eNOS).

Recently, concerns about the safe upper level of vitamin D have been raised and a reverse J or U shaped relation has been described with 25-OHD level and mortality.]